“No matter how you limit contacts, it’s impossible to avoid communication with people while drafting decisions,” Putin said.
The Prime Minister held a cabinet meeting via video link on Thursday and he last saw Vladimir Putin in person on the 24 of March.
Officials are concerned other members of the cabinet may have been infected.
But Mishustin’s spokesman, Boris Belyakov, said the prime minister mostly relied on video calls to communicate during the pandemic and had direct contact with a very narrow circle of people. They have now self-isolated and will be tested for the coronavirus.
COVID-19 in Russia
In Russia, more than 100,000 people are now infected and over a thousand have died of COVID-19. The daily number of infections spiked on Thursday with 7,099 new cases reported.
The Kremlin insists the situation is under control and that sharp increases can be expected as the virus spreads through Russia.
But there are reports that hospitals are not ready and that Russians are not sufficiently concerned by the risk of infection.
Related:Does Russia really have coronavirus under control?
And the Mayor of Moscow says he doesn’t think the Russian capital is close to overcoming the spread of coronavirus.